Only run as an experiment myself but Wazuh can do it apparently: https://documentation.wazuh.com/current/proof-of-concept-guide/detect-malware-yara-integration.html

MDE can do something similar but you’ll need to rewrite your rules which is of course more than suboptimal… https://learn.microsoft.com/en-us/defender-xdr/advanced-hunting-overview?view=o365-worldwide

Can confirm that on Android with Firefox mobile + ublock origin the ads wouldn’t load and you were able to skip quite fast. (Not agreeing with the ads being displayed at all, that’s just a greedy move)